If you have spiders in your home, you might be looking for ways to get rid of them. Indoor spiders are common, but they can be a burden. The following tips will help you to get rid of the current spider problem and prevent more problems in the future. Seal Off the Home Before you start exterminating the spiders, make sure you prevent any more from coming inside. Spiders can get in through even the tiniest holes and cracks, so start there.